"All humans have one thing in common, and that is food. We all must eat to survive. The gut is continually and constantly in contact with food and food antigens, and most foods contain chemicals, even those that are labeled “organic.”
These chemicals include not only artificial colorings, additives, flavorings, dyes, and preservatives, but also food contact materials, such as conveyer belts and food packaging materials. We must also take into consideration chemicals in agriculture, including pesticides, herbicides, fungicides, and artificial fertilizers.
The gastrointestinal mucosal immune system, as it relates to food, starts by being besieged by a wide variety of microorganisms, first from the mother’s birth canal or skin if via Caesarean section and by the handling by medical personal, then by breast milk or commercial formula, and eventually by food and food antigens. The mucosal immune system is our first line of defense against chemicals, microbes, and dietary components, and it lines the intestinal tract and respiratory tract. This is why the gut mucosa consists of the largest assemblage of lymphoid tissue in the body. When in a state of balance, the microbiota, specific bacteria, and their products provide immune protection.
Bacterial toxins, chemicals, foods, and undigested proteins and peptides can induce systemic food immune reactivity by causing failure of immune tolerance. Immune tolerance is the immune system’s ability to recognize what is harmful and what is not. If immune tolerance is lost, then inflammation ensues and autoimmunity can occur. Factors that can affect immune tolerance and oral tolerance are the exposure to toxic chemicals and the diet of the mother during pregnancy, whether the child is born via the birth canal or via Caesarean section, breast-feeding versus commercial formula feeding, the timing of the introduction to solid foods, gut microbiota, digestive enzymes, use of medication or drugs by the mother during pregnancy and during breast-feeding, the child, and genetics. Therefore, the perinatal period is essential in establishing oral tolerance.
Approximately 1 ton of food goes through our gut every year, including more than 220 pounds of proteins, attesting to the fact of the effectiveness of the immune system in protecting us from adverse reactions. The disturbance of this homeostasis of the immune system by environmental factors can lead to food immune reactivities, bringing about the penetration of dietary proteins and peptides into the submucosa. What can disturb this delicate but very effective balance? '
What we eat now as compared with the diet even 2 or 3 generations ago, and back to the beginning of human history, is vastly different. As mentioned earlier, we now have artificial sweeteners, artificial colorings, artificial flavorings, artificial preservatives, and a number of other food additives. The majority of Americans eat processed foods. Plastic containers are ubiquitous in our society for both foods and liquids. We microwave our foods and use coated cookware for food preparation. All these add chemicals to the foods and liquids we consume, which then bind to food antigens. These chemicals can bring about failure of oral tolerance, increased intestinal permeability, binding of food components to human tissue antigens, and molecular mimicry and crossreactivity between food antigens and human tissues, resulting in autoimmunity.
The process of digestion of foods begins with the breakdown of proteins into peptides and then into amino acids. These are then absorbed by the gut. However, this process is affected by a multitude of factors: medications, processed foods, lack of digestive enzymes, and chemicals in foods. Think of the overuse in our society of antacids, antihistamines, histamine-2 blockers, and all available overthe- counter and antibiotics in our society. These interfere with the proper digestive processes and our gut is frequently presented with partially undigested foods, proteins, and peptides, which changes the microbiota and brings about the release of endotoxins by bacteria known as lipopolysaccharides. The lipopolysaccharides bring about inflammation, which opens up the tight junctions, damaging occludin, zonulin, and actinomycin, allowing these proteins and peptides to cross the mucosal layer, which then migrate into the regional lymph nodes and into then into the circulation. These peptides can bind to tissues, stimulating an attack by the immune system and causing autoimmunity. ...
It is very interesting to read how some meats contain meat glue, a mixture of meat, transglutaminase, casein, chemical preservatives, and chemical colorings.
The clinician is faced with patients whose initial symptoms are vague and nonspecific, such as fatigue, joint aches and pains, sleep disturbance, brain fogginess, wide mood swings, cognitive function problems, changes in bowel habits, numbness and tingling, and a general feeling of malaise. The more specific symptoms of autoimmunity take longer to develop.
There is good news in all this: There are laboratory analyses that can detect these antibodies early, years before the reactions with the immune system appear that cause the irreversible and chronic damages that lead to autoimmunity. ..."
Andrew W. Campbell, MD
Editor in Chief, Alternative Therapies
Micronutrients is a term generally used to define all essential vitamins and minerals mainly taken from food sources and which are necessary for vital functions. Micronutrients consist only of 0.01 % of body mass. Surprisingly, even if the amounts required are very low, a lack of micronutrient can lead to severe, non-ignorable health disorders, even threatening for life. Fortunately, most of these dysfunctions can disappear after the administration of the elements in lack.
The most frequent deficiency is that of iron, followed by vitamin A, folate, iodine, and zinc deficiency.
Micronutrients are indispensable for a variety of vital functions. Micronutrient deficiencies are a global problem concerning two billion people. In most cases, deficiencies are treatable with supplementation of the elements in lack. Drug-nutrient interactions can also lead to micronutrient reduce or depletion by various pathways.
Supplementation of the elements and long-term fortification programs for populations at risk can prevent and restore the related deficiencies.
Within the context of Predictive, Preventive, and Personalized Medicine, a multi-professional network should be developed in order to identify, manage, and prevent drug-micronutrient interactions that can potentially result to micronutrient deficiencies.
We may coordinate with other practitioners to provide these services, as needed.
Contained in the nucleotides of DNA are the genetic instructions for every function in the human body. Traditionally, DNA is explained in terms of dictating individual appearance, hair and eye color, height and it remains true in regards to enzymatic pathways, receptor function and ultimately the precise requirements for exercise, diet and nutritional supplements.
Genetic makeup and expression exerts considerable influence over an individual's metabolic function and exercise physiology. There is extensive evidence that supports the direct interaction of genes with overall physiological processes of metabolic function and obesity and shows the intricate interaction(s) of polymorphism(s) that alter the degree or severity of metabolic disorders or resistance to weight loss.
Organic acid testing is a way to measure whether your body is getting and using nutrients to drive optimal health. Nutrients are protecting agents. Just as your car has additives and devices that protect it, nutrients serve to protect your heart, brain, and other critical organs. Like a car’s gauges warn of potential problems, your body has certain chemical indicators, known as organic acids, that can alert you to potential problems. Also measured are markers that assess intestinal health, neurotransmitter activity, and detoxification demands. Early warnings can help you make diet and lifestyle changes that may both extend and enhance your quality of life.
Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.
Many chronic health problems can be difficult to diagnose, especially whan they involve nonspecific symptoms such as fatigue, foggy thinking, gastrointestinal upset, joint aches, sleep cycle disturbances, and more. Standard medical testing is designed to identify disease states. Organic acid testing does not diagnose disease; it helps to give insight to the underlying causes of disease.
The Organic Acid Comprehensive Profile measures many vitamin compounds that provide evidence of your need for virtually all B-vitamins. Also included are organic acids produced by intestinal bacteria and yeasts, as well as products of detoxification. The Profile will also help assess specific metabolic dysfunctions that are used to customize a nutritional program to help you mange those areas in need of support. This allows an approach that treats the cause of disease, not just the symptoms. The goal is to identify dysfunctions related to nutritional deficiencies and correct them before disease is allowed to develop. More specifically, The OACP is valuable for determining the following:
• Insufficiencies of carnitine and NAC
• Specific markers of bacterial dysbiosis
• Lipoic acid and CoQ10 sufficiency
• Functional status of B-vitamins
• Neurotransmitter metabolism
• Mitochondrial energy production
• Methylation sufficiency status
• Detoxification adequacy
• Oxidative stress and antioxidant sufficiency
From a single urine specimen, the Organic Acid Comprehensive Profile provides important information for treating the following conditions and more:
Anxiety, attention and memory disorders, autoimmune disorders, bloating and gas, blood sugar dys-regulation, constipation, depression, dermatitis, ear, nose, and throat symptoms, fatigue, headaches, hypertension, liver disease, mood changes, multiple chemical sensitivity, muscle and joint pain, nausea, reflux, sleep abnormalities, and weight gain.